https://youtu.be/HVu18jJkMP8
Bed bugs are the world’s best hitchhikers invading pristine homes and are not a hygiene-related pest. Now some have developed 15 % thicker outer shells that are able to resist some insecticides. The bugs use enzymes to break down the insecticides called metabolic detoxification. The cuticle slows the insecticide down giving the enzymes more time to act therefore double the protection equals an extra factor. Also, 18 per cent of bed bugs are highly resistant to a pyrethroid-based chemical common in treating bed bugs. The new chemicals that have been developed, such as the neonicotinoids, are already showing signs that bed bugs are developing resistance to these chemicals as well. Non-chemical controls such as vacuuming before treatment or applying desiccant dust that dry out the bugs are helping to killing them. Also, heat treatments in furniture can also be used: all life stages die at temperatures above 45 degrees.
https://www.linkedin.com/pulse/bed-bugs-22-5-factor-randy-bilesky?published=t
http://www.delta-optimist.com/opinion/blogs/blog-bed-bugs-2-2-5-factor-1.2231590