https://youtu.be/znTUdWIEaEQ
Bed bug are now 33,333 times more resistant and increasingly immunity to neonicotinoids, or neonics, and pyrethroids. According to a report in the Journal of Medical Entomology, bed bugs have developed a resistance to neonics, the most widely used group of insecticides for controlling them. After testing, researchers have found that it took several thousand times more of the chemical acetamiprid to kill off the bed bugs. They think detoxifying enzymes developed from a pyrethroid (common pest control spray) tolerance helped them fend off the new chemicals. The insecticides now used are no longer as effective as they used to be. Products with different modes of action need to be considered, along with the use of non-chemical methods.
http://www.delta-optimist.com/opinion/blogs/deltabc-1.983313/blog-bed-bugs-part-ii-resistance-to-widely-used-pesticides-1.2161980