https://youtu.be/jS7LlEAQh3s
Mice skin cells are predetermined to be sweaty or hairy, and their fate is determined by competing signals, during the embryonic growth. Mice have different skin cells that develop hair follicles on their back and designated skin cells that develop sweat glands on their paws. The mice skin cells differ from their hairy backs to their sweaty paws. Mammals are different than humans, as they have to pant and seek shade to cool down where we can cool down through sweating. This is due to the distinctiveness of the human skin; hair and sweat glands are generated in the same area of the body. In mice, it was discovered that BMPs (mesenchymal-derived bone morphogenetic proteins) were found to be a lot higher in the foot skin cells than the skin cells on the back of the mice. The protein, Bmp5 was responsible for differentiating the skin cell outcomes. Researchers have found that by blocking Bmp5 in the foot skin of mice, the number of sweat glands generated during embryonic development can be reduced. This discovery might help in skin regeneration therapies in future.
http://www.delta-optimist.com/opinion/blogs/blog-ever-seen-a-sweaty-mouse-1.5575304