Marathon mice get runners high

A certain hormone called leptin, nicknamed the “satiety” hormone, has been found in mice as another ingredient to a runner’s happiness. It is called “fat hormone” as this is generated by fat cells. Increased leptin level sends a signal to the brain indicating you are “full” thus resulting in increasing the metabolic rate.

However, when leptin level decreases, it signifies hunger. Metabolism, hunger and energy expenditure are primarily regulated by leptin. This hormone not only enriches mood but also enhances brain function, mental sharpness and boosts better memory. Normal mice ran at about six kilometers per day, while genetically engineered mice ran almost two times faster, achieving a runners high. Marathon runners are driven by the insufficient amount of leptin levels and desire to run is urged because of inadequate leptin.

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