Mice show that Sleep is “rebooting the brain”  

Scientists studying mice have discovered that a key purpose of sleep is to recalibrate the brain cells responsible for learning and they have discovered several important molecules that govern the recalibration process. Now there is more evidence that sleep deprivation, sleep disorders and sleeping pills can interfere with the process. The mouse brain can only store so much information before it needs to recalibrate and without sleep and the recalibration that goes on during sleep, memories can be lost. Scientists believe memories are encoded through synaptic changes and these synapses are restructured throughout the mouse brain every 12 hours or so. The need for sleep is controlled by adenosine, a chemical that accumulates in the brain as an animal stays awake, provoking sleepiness. Sleeping on it, can actually clarify your ideas and that sleep is not really downtime for the brain.  Caffeine, the world’s most widely consumed psychoactive drug, directly interferes with adenosine.

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http://www.delta-optimist.com/opinion/blogs/blog-mice-show-that-sleep-is-rebooting-the-brain-1.9714085

https://www.linkedin.com/pulse/mice-show-sleep-rebooting-brain-randy-bilesky?published=t